What is Telmisartan?
Telmisartan is an angiotensin II receptor blocker (ARB) that is used to treat high blood pressure and reduce the risk of cardiovascular events in adults and children with certain conditions. It works by blocking the binding of angiotensin II to the AT1 receptors in the body. This helps relax blood vessels, allowing blood to flow more smoothly and lowering blood pressure.

How it works in the body
Telmisartan in Angiotensin II is a hormone that causes blood vessels to narrow and tighten. This increases blood pressure. Telmisartan prevents angiotensin II from binding to AT1 receptors located mainly in the blood vessels, kidneys and adrenal glands. By blocking this binding, it allows blood vessels to stay relaxed and dilated. This helps lower blood pressure and improves blood flow throughout the body. Telmisartan also reduces sodium and water retention by the kidneys, which aids in reducing blood pressure levels.

Approved uses of Telmisartan
Telmisartan is primarily used for the treatment of essential hypertension or high blood pressure in adults. It is effective at lowering both systolic and diastolic blood pressure over a 24 hour period. Telmisartan is also approved to reduce the risk of cardiovascular events such as heart attack, stroke or death in adults who are at high risk due to pre-existing heart or kidney disease or diabetes. It helps prevent complications from high blood pressure and protects vital organs from damage over time.

Telmisartan vs other ARBs
Telmisartan is comparable to other ARBs like losartan, valsartan and irbesartan in terms of lowering blood pressure levels. However, some studies show that telmisartan may provide additional benefits beyond blood pressure control compared to other ARBs. It appears to have a longer half-life and causes less irritation of the respiratory system. Telmisartan also does not seem to increase blood potassium levels like other ARBs. This is an advantage for people suffering from kidney disease or diabetes.

Safety profile of Telmisartan
Overall, Telmisartan is well-tolerated by most adults. Common side effects include dizziness, headache, fatigue, back or leg pain and diarrhea. These side effects are usually mild and often subside on their own within a few days. Serious side effects are rare but can include low blood pressure, poor liver function or allergic reactions like rash or swelling in the mouth. Telmisartan should not be taken during pregnancy as it may harm the developing fetus. Patients are advised to consult their doctor before use if they have liver or kidney disease. Proper monitoring is necessary if taken with other medications.

Dosage guidelines

The standard starting dosage of Telmisartan is 40 mg once daily, usually in the morning. The dose may need to be increased up to 80 mg daily depending on the individual's response to treatment and blood pressure level goals. The maximum recommended dose is 80 mg daily. Telmisartan may be taken with or without food as food does not affect its absorption. As with any blood pressure medication, patients should take Telmisartan regularly as prescribed to achieve optimal results and continue treatment even when feeling well to prevent recurrence of high blood pressure.

In the Telmisartan is an effective long-acting ARB medication for reducing high blood pressure and improving cardiovascular health outcomes. With an acceptable safety profile, it provides a well-tolerated treatment option for adults needing to control their blood pressure. When taken as prescribed under medical guidance, Telmisartan helps maintain healthy blood pressure levels and protects vital organs from long term damage.

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